The film includes transsexual characters or references, as noted in LGBTQ representation studies. However, specific details regarding their portrayal, tone, or narrative impact are not available, preventing an assessment of whether the depiction is primarily positive, negative, or affirming.

The film features Greg Heffley and Rowley Jefferson, characters originally depicted as white in the source material, voiced by African American actors. This casting choice represents a clear departure from their established racial portrayals, aligning with the definition of a race swap.

The film portrays Christianity through the Heffley family's participation in church activities, including a Christmas service, and involvement in a Boy Scout-like group. It emphasizes traditional symbols, cultural aspects, and values such as community, family, and moral development, presenting them in a respectful and affirming manner without critique.