The film "Megamind: The Button of Doom" does not feature any identifiable LGBTQ+ characters or themes. The narrative focuses solely on the established characters and their comedic adventures, without incorporating elements related to queer identity or experiences.

This animated short film does not feature any identifiable transsexual characters or themes. The story centers on the main characters' comedic misadventures with a giant robot, with no elements pertaining to gender identity or related social issues.

The film features Roxanne Ritchi as the primary female character, but she does not engage in physical combat. While female villains Lady Doppler and Hot Flash are present, their combat methods rely on superpowers rather than direct physical confrontation against male opponents.

All established characters from the original "Megamind" film maintain their canonical genders in this sequel short. New characters introduced in "The Button of Doom" do not count as gender swaps.

This animated short film is a direct sequel to the 2010 movie "Megamind." All returning characters maintain their original established appearances and racial/species depictions from the preceding film, with no changes to their race.