No LGBTQ+ characters or themes appear in the film. The story centers on a 16th-century family's grief and creative response to loss, emphasizing heterosexual relationships and parental bonds.

No transsexual characters or themes appear in the film. The story explores family bonds and loss in 16th-century England, centered on Agnes Hathaway and William Shakespeare's household, including their children's playful twin disguises that do not engage with gender identity.

The movie does not contain any action or adventure elements.

The adaptation portrays historical figures William Shakespeare as male, Agnes Hathaway as female, and son Hamnet as male, aligning with the source novel and historical records without altering genders.

Hamnet adapts Maggie O'Farrell's novel about Shakespeare's white English family, with white actors portraying Agnes, William, and Hamnet, matching the historical and literary baseline without any racial mismatches.