High Art provides an affirming portrayal of lesbian characters and relationships. The central romance is depicted with dignity, complexity, and emotional depth, validating the worth of their queer identities and love. While addressing themes of addiction and tragedy, these are external forces, and the narrative consistently respects the characters' experiences.

The film "High Art" features Greta, a transsexual woman, as a supporting character. Her portrayal is dignified and complex, integrated naturally into the narrative without her identity being a source of mockery or central conflict. The film treats Greta with respect, affirming the worth of her character within the story's bohemian setting.