Based on the provided movie details and the absence of additional information, it is not possible to determine the presence or portrayal of LGBTQ+ characters or themes in 'James, 2022'. Therefore, an accurate assessment cannot be made.

Currently, there is not enough information available to assess the film's portrayal of transsexual characters or themes. Without specific plot details or character arcs, a definitive evaluation cannot be made regarding any potential positive, negative, or neutral depictions.

Based on the available information, there are no specific details or descriptions of scenes where a female character engages in and wins close-quarters physical combat against one or more male opponents. The primary action focus of the film appears to be on the male lead.

There is no information provided regarding source material, previous adaptations, or historical figures for the film "James" (2022). Without a baseline for character genders, it is not possible to determine if any gender swaps occurred.

The film "James" (2022) is an original production, and no prior source material, historical figures, or previous adaptations are indicated. Therefore, its characters are new, and there is no established canonical race from which a swap could occur.