This adaptation of Macbeth includes instances of gender swapping for established characters. Ross, a male Thane in the original play, is portrayed by a female actor. Similarly, Malcolm, King Duncan's son, is also depicted by a female actor.

The 2025 production of Macbeth features several characters portrayed by actors of a different race than their established historical or canonical depictions. Lady Macbeth, traditionally depicted as white, is played by a Black actress. Similarly, Ross and Macduff, also historically white Scottish characters, are portrayed by actors of different racial backgrounds.

The narrative depicts a marriage driven by ambition and manipulation, where traditional gender roles are subverted. This destructive partnership leads to regicide and the brutal annihilation of innocent family units.