Madea's Destination Wedding does not feature identifiable LGBTQ+ characters or themes. The film's narrative centers exclusively on heterosexual relationships and family dynamics, with no explicit representation or exploration of LGBTQ+ presence or issues according to available information.

Based on available information, Madea's Destination Wedding (2025) does not feature any transsexual characters or explore themes related to gender transformation. The narrative focuses on family drama and comedic interactions, with no storylines or character arcs involving transsexual identity, thus resulting in no depiction.

The movie does not contain any action or adventure elements.

The film features Madea, a female character consistently portrayed by male actor Tyler Perry. This is a performance involving gender disguise within the story, not a change to the character's canonical gender, thus it does not meet the definition of a gender swap.

The film continues the established racial portrayals of its main characters, who have consistently been African American throughout the Madea franchise. There is no indication of any character's race being changed from prior canon.