Based on available plot summaries and thematic discussions, Novocaine does not feature any identifiable LGBTQ+ characters or themes. The narrative focuses on a heterosexual relationship and the protagonist's struggles, indicating no explicit or significant portrayal of the LGBTQ+ community.

Based on current information, Novocaine (2025) does not appear to feature transsexual characters or explore themes related to gender and sexual transformation. The film's narrative focuses on action, dark comedy, and thriller elements, centered on a man who cannot feel pain. No plot points or character arcs suggest any engagement with transsexual identities or experiences.

Based on available information, the film's plot centers on a male protagonist, Nate, and his fights against male adversaries. There are no public records or descriptions of female characters engaging in or winning direct physical combat against male opponents.

The film is an original story, not based on pre-existing source material or historical figures. Consequently, no characters have a prior established gender from source material or history that could be subject to a gender swap.

The film features original characters without prior established racial identities in source material, previous installments, or real-world history. While two siblings are portrayed by actors of different races, this does not constitute a race swap as there is no pre-existing canon to diverge from.