Operation Mekong is an action-packed film centered on a police mission to dismantle a drug cartel. The narrative is entirely focused on this objective, with no presence of LGBTQ+ characters, themes, or related plot developments.

The film "Operation Mekong" is an action-thriller based on a true story about a drug bust. There are no identifiable transsexual characters or themes present in the narrative, thus the portrayal is not applicable.

The film primarily focuses on male protagonists and antagonists in action sequences. While female characters are present, none are depicted engaging in or winning close-quarters physical combat against one or more male opponents using martial arts, skill, or melee weapons.

Operation Mekong is based on a real-life event, the Mekong River massacre. The film's main characters are either based on real historical figures whose gender aligns with their portrayal or are original characters created for the film, thus not constituting a gender swap from established canon or history.

The film is based on a real-life event involving Chinese and Southeast Asian individuals. The main characters and historical figures are portrayed by actors of the same broader racial categories (e.g., Chinese actors playing Chinese officers, Thai actor playing a Burmese drug lord), aligning with the source material and historical context. No character's race was changed from its established baseline.