Poor Things offers a primarily positive portrayal of LGBTQ+ themes through Bella's respectful and emotionally deep relationship with Toinette, a Black lesbian sex worker. Despite the queer story arc being incomplete, the film treats queer characters as significant, affirming their dignity and presence within the narrative.

Poor Things uses the character of Bella Baxter as an allegory for trans identity, exploring themes of self-creation, autonomy, and liberation. Her journey of joyful self-discovery and resistance to societal control resonates with trans narratives of self-ownership and transformation. The film celebrates self-reinvention, portraying Bella as an empowered figure and challenging negative societal perceptions, resulting in a net positive and affirming depiction of these themes.