LGBTQ+ characters dominate the ensemble, depicted with vibrant authenticity as drag performers, trans individuals, and queer allies who wield agency and wit against undead hordes. The narrative affirms queer community as a source of strength and joy, free from mockery or degradation, celebrating identity through playful, respectful horror-comedy.

Trans characters receive an affirming portrayal, depicted with dignity and complexity as integral to a vibrant queer community facing zombies. Sam's journey of reclaiming performance mojo amid chaos underscores the film's empathetic validation of trans lives and solidarity.

The film portrays the queer nightclub ensemble as a chosen family bound by solidarity and performance, with fluid gender roles and casual relationships normalized amid the zombie outbreak. Traditional family elements, like a pregnant character's marriage, appear peripherally but are overshadowed by critiques of homophobia and celebrations of alternative community bonds.

The film satirizes Christianity through a prologue featuring a closeted pastor who turns into a zombie after attacking a queer performer in a church, portraying the faith as hypocritical and oppressive to queer identities. This negative depiction extends to perverse communion imagery and a Catholic-themed drag show on Easter, reinforcing religion's draining influence without counterbalancing nuance.