Wendell & Wild features Father Best, a trans man, subtly depicted through visual cues and confirmed by the creators. He is portrayed as a kind, supportive, and positive character, with his trans identity presented without negative framing or stereotypes, contributing to an affirming and inclusive representation.

Wendell & Wild features Raul, a trans boy, as a supportive friend to the protagonist. His trans identity is portrayed positively and affirmed within the narrative, notably when he casually states his pronouns and identity, which is accepted without issue. The film depicts his character with dignity and respect, avoiding stereotypes or negative framing.

The film portrays Christianity through a Catholic all-girls school and its nuns. While the institution is struggling, key figures like Sister Helley are depicted as wise and supportive, guiding the protagonist through her trauma. The narrative does not critique the faith itself but rather uses the setting as a backdrop for a story about personal growth and fighting corruption.