Sicario does not feature any identifiable LGBTQ+ characters or themes. The narrative is solely focused on the brutal realities of the drug war, leaving no room for the exploration or depiction of queer identities or experiences within its plot.

Sicario does not feature any identifiable transsexual characters or themes. The film's entire focus is on the brutal realities of the drug trade and the ethical compromises made by those fighting it, rendering the concept of trans representation irrelevant to its narrative.

The film features Kate Macer, an FBI agent, as the primary female character in action. While she participates in firearm-based engagements, there are no scenes depicting her achieving victory in close-quarters physical combat against one or more male opponents. In a direct physical confrontation, she is overpowered by a male assailant.

Sicario is an original screenplay, not an adaptation of existing material or a biopic. All main characters were created for this film, thus lacking a prior canonical or historical gender to be swapped from.

Sicario (2015) is an original film with an original screenplay and characters. There is no prior source material, historical record, or previous installment to establish the canonical race of any character. Therefore, no character could have been portrayed as a different race than originally established.