The film features Winston, a trans man, whose character is handled with dignity and empathy. His struggles with his mother's acceptance are presented as external obstacles, and his identity is not a source of ridicule, leading to an affirming portrayal.

Sunshine Cleaning features Norah, a transsexual woman, as a loving and stable partner. While Rose's father initially struggles with Norah's identity, the narrative frames his prejudice as a flaw he overcomes, ultimately accepting and defending her. The film portrays Norah with dignity and empathy, affirming her worth and relationship, resulting in a net positive depiction.