Due to a lack of available information regarding the plot, characters, or themes of 'The Uranium Conspiracy, 1978', it is not possible to assess the film's portrayal of LGBTQ+ individuals or themes. There is insufficient data to determine any net impact.

Based on the available information for 'The Uranium Conspiracy, 1978', there is insufficient data to assess the portrayal of transsexual characters or themes. No details regarding their presence or specific narrative arcs were provided, making it impossible to determine a net impact.

While Janet Agren's character, Ann, is described as a resourceful agent involved in action and hand-to-hand combat, specific details confirming her victory in close-quarters physical combat against one or more male opponents are not available from accessible plot summaries or reviews. Therefore, a definitive assessment cannot be made.

Without information on source material, previous adaptations, or historical figures for 'The Uranium Conspiracy' (1978), it is impossible to determine if any character's gender deviates from an established baseline.

The Uranium Conspiracy is an original 1978 film, not an adaptation of existing source material or a reboot with pre-established character races. Therefore, no characters could have been race-swapped from a prior canon.