Unstoppable is an action thriller centered on a runaway train. The film does not feature any identifiable LGBTQ+ characters, themes, or plot elements, resulting in no portrayal of LGBTQ+ issues.

The film "Unstoppable" does not feature any identifiable transsexual characters or themes. Its narrative is solely centered on an action-thriller plot involving a runaway train, therefore, the portrayal of transsexual individuals or issues is not applicable.

The film primarily focuses on two male protagonists attempting to stop a runaway train. The main female character, Connie Hooper, is a yardmaster who directs operations from a control room. No female characters are depicted engaging in or winning physical combat against male opponents.

Unstoppable (2010) features original characters created for the film, loosely inspired by a real-life incident. There are no pre-existing canonical or historical characters from source material, previous installments, or documented history whose gender was altered for this portrayal.

The film "Unstoppable" features original characters created for this specific movie, rather than adapting pre-existing characters from source material or directly portraying specific historical figures with established races. Therefore, no race swap occurs.