Based on currently available information, 'Sinners, 2025' does not appear to feature transsexual characters or themes. The film's plot, cast, and thematic descriptions do not include any elements related to transgender representation, preventing an assessment of its portrayal.

Based on available information, promotional materials, and reviews for *Sinners* (2025), there are no documented scenes depicting female characters engaging in or winning close-quarters physical combat against male opponents. The film's narrative focuses on male protagonists confronting supernatural elements.

The film features original characters created for its narrative, such as Smoke, Stack, Annie, and Mary. These characters lack prior canonical or historical gender identities, meaning there is no source material or historical record against which to compare their on-screen gender for a swap.

The film's casting aligns with characters' established backgrounds and the historical 1932 Mississippi Delta setting, including African American, white, Native American, and Chinese portrayals. No character established as one race in source material or history is depicted as a different race.