2 Broke Girls frequently utilizes LGBTQ+ characters and themes as sources of stereotypical humor and mockery. While not overtly malicious, the portrayals often lack dignity and complexity, reducing characters to caricatures for comedic effect without offering counterbalancing perspectives or affirming narratives. The net impact is primarily negative due to the reliance on harmful stereotypes.

2 Broke Girls features Jery, a trans woman character whose identity is primarily used for comedic effect. The portrayal often relies on stereotypes and the shock value of her transition, leading to humor derived from her gender identity and other characters' discomfort. While she is eventually accepted, the narrative lacks depth or respectful affirmation, resulting in a net negative impact due to problematic comedic framing.

The show frequently uses Christianity and its adherents as targets for irreverent humor, often playing on stereotypes of hypocrisy, naivety, or outdated beliefs. There is no significant counterbalancing positive or nuanced portrayal, reinforcing negative comedic stereotypes.

Judaism is primarily depicted through character-driven jokes that often rely on cultural stereotypes, such as those related to Jewish mothers or professions. The narrative offers no positive or nuanced counter-portrayal, using these stereotypes for comedic effect.