A Million Little Things offers a predominantly positive portrayal of LGBTQ+ characters and themes. Key storylines, such as Danny Dixon's coming out and Stephen's journey, depict queer identity with dignity, complexity, and strong family support. Even tragic elements, like Chad's story, are handled with empathy, affirming the worth of LGBTQ+ lives.

A Million Little Things features Tyrell, a non-binary character whose journey of self-discovery and coming out is depicted with sensitivity and respect. The show emphasizes the importance of family support and understanding, portraying the character's identity as a source of strength and authenticity rather than conflict or ridicule. The overall impact is affirming.

The series respectfully portrays Christianity as a source of comfort, moral guidance, and community for characters like Ashley and Javier. Their faith is depicted as a genuine aspect of their lives without critique or satire.

Judaism is depicted positively through characters like Gary and his father, Javier. Their Jewish heritage and traditions are shown as integral to their identity, family connections, and cultural celebrations, integrated naturally into the narrative.