Agatha Raisin features recurring and minor LGBTQ+ characters, most notably Roy Silver, Agatha's openly gay publicist. These characters are consistently depicted with dignity, complexity, and agency. Their relationships and identities are treated as normal aspects of the community, integrated into the narrative without being a source of mockery, villainy, or negative stereotypes, resulting in a net positive portrayal.

The character Bill Wong, who is explicitly described as being of Chinese descent in the source novels, is portrayed by a white actor in the television adaptation, constituting a race swap.