The series features characters with implied LGBTQ+ orientations, such as Najenda and Leone. Their identities are presented incidentally, without being central to the plot or used for mockery or affirmation. The portrayal avoids both strong positive and negative arcs, integrating these aspects as neutral elements of characterization.

The series features multiple female characters who are highly skilled combatants. Akame, a master swordswoman, repeatedly defeats male opponents in close-quarters combat using her katana. Leone, with her enhanced physical abilities, also frequently overpowers male adversaries in hand-to-hand fights.

The narrative strongly emphasizes the formation and celebration of chosen family bonds among its protagonists, often in place of or due to the destruction of biological family units. Traditional family structures and norms are largely absent from the central positive portrayals.