Alphas features a bisexual recurring character, Kathy Sullivan, whose sexuality is depicted as an incidental aspect of her complex personality. It is neither a central theme nor a source of strong positive affirmation or negative stereotyping, contributing to a neutral overall portrayal.

The show 'Alphas' features Skylar, a trans woman and Alpha, whose identity is acknowledged but not central to her character or the plot. Her portrayal is neutral, presenting her as a complex and capable individual without using her trans identity for explicit positive affirmation or negative stereotypes.

The show features Dani Rosen, a female Alpha with super strength, who engages in and wins close-quarters physical fights against multiple male opponents, demonstrating superior physical power.