Arcane does not feature any identifiable transsexual characters or themes within its narrative. The series focuses on other aspects of identity, class, and relationships, thus rendering the portrayal of transsexual identity as N/A due to its absence.

Arcane adapts characters from the League of Legends universe. All major characters originating from the game maintain their established gender in the show. New characters created for Arcane do not count as gender swaps.

Arcane adapts characters from the 'League of Legends' video game. The show maintains the established visual and racial depictions of its existing characters, and new characters introduced in the series do not constitute race swaps.