Chicago Med consistently portrays LGBTQ+ characters and themes with dignity and empathy. Characters are given complex arcs where their queer identity is normalized, and patient storylines often highlight LGBTQ+ experiences respectfully, contributing to an overall affirming depiction.

Chicago Med generally portrays transsexual characters with dignity and empathy, often through patient storylines. Doctors typically advocate for respectful care, correcting misgendering, and addressing external prejudice. While challenges are depicted, the show's overall stance affirms trans identities and experiences, ensuring the net impact is supportive and validating.

The show frequently depicts Christian characters and patients, often portraying their faith as a source of comfort, moral guidance, and strength in challenging medical situations. While individual characters may face dilemmas related to their beliefs, the narrative consistently treats Christianity with respect and nuance, affirming the dignity of its adherents.

Chicago Med portrays Muslim characters and patients with sensitivity, often exploring their faith and cultural practices in a respectful manner. The show highlights Islam as a source of strength and identity, generally framing any challenges as external misunderstandings rather than inherent flaws within the religion.

Judaism is portrayed with respect for its traditions and adherents. When Jewish characters or practices are featured, the narrative focuses on their cultural and religious significance, presenting them as integral and respected aspects of individual identity without negative framing.