Claws features prominent LGBTQ+ characters, most notably Polly Marks, whose bisexuality is depicted with complexity and agency, including a significant lesbian relationship. The show also sensitively portrays an autistic character's relationship with a transgender woman. Overall, LGBTQ+ identities are integrated naturally into the narrative, treated with dignity, and contribute to the show's diverse and affirming portrayal of relationships.

Claws features Virginia, a prominent transgender character, whose identity is portrayed with dignity and respect. Her loving relationship with Dean is a central narrative element, and she is depicted with complexity and agency, contributing significantly to the show's plot without her trans identity being a source of mockery or degradation.

The show prominently features Uncle Daddy, a crime boss who uses a twisted, hypocritical version of Christianity to justify his violent actions and control his family. The narrative critiques this abuse of faith as a tool for oppression and crime, reinforcing a negative portrayal of such religious adherence.