The show 'Constantine' includes subtle allusions to the protagonist John Constantine's bisexuality through mentions of past male lovers. These references serve to flesh out his character and backstory but are not central to the plot or explored in depth, resulting in an incidental portrayal that neither strongly affirms nor denigrates.

The character Zed Martin, who is depicted as white in the source comics, is portrayed by Angélica Celaya, a Latina actress, in the show. This constitutes a race swap.

The show's entire cosmology is built upon Christian mythology, affirming the existence of God, angels, demons, Heaven, and Hell as objective realities. While it critiques human and even angelic institutions for corruption and hypocrisy, it never undermines the fundamental truth or significance of the Christian supernatural framework, positioning the struggle against evil as necessary.