Degrassi consistently portrays LGBTQ+ characters and themes with significant depth and empathy. The show features diverse queer characters whose journeys of self-discovery, relationships, and challenges are depicted in an affirming and validating manner, often highlighting the importance of acceptance and support within their communities.

Degrassi: The Next Generation featured Adam Torres, a pioneering trans boy character. His storyline explored coming out, family acceptance, and dating challenges with dignity and empathy. The show depicted external obstacles, affirming the worth of trans lives, and his tragic death did not diminish the overall positive portrayal.

The show portrays Christianity with nuance and respect, exploring characters' personal faith journeys, moral dilemmas, and the role of Christian values in their lives. It often critiques individual hypocrisy rather than the faith itself.

The series portrays Islam with depth and actively works to counter stereotypes, showcasing Muslim characters' experiences, cultural practices, and challenges with Islamophobia, positioning the audience to sympathize.

Judaism is depicted respectfully as a source of cultural identity, community, and tradition for characters, with storylines exploring holidays and personal connections to the faith.