Drawn Together features LGBTQ+ characters whose identities are primarily exploited for shock humor and crude gags. While the show targets all groups with offensive humor, its portrayal of queer characters often relies on harmful stereotypes and depicts their sexuality or gender expression in demeaning or predatory ways, lacking any affirming or respectful counterbalance.

Drawn Together consistently portrays transsexual characters and themes in a negative light, primarily through Captain Hero's disgusted reactions to trans women. The show utilizes transphobic humor, slurs, and stereotypes without offering any affirming or critical perspective, reinforcing harmful tropes.

The show frequently uses Christian themes and characters, particularly Clara, for crude humor and satire, often portraying piety as naive, hypocritical, or a source of judgmentalism, without offering a counterbalancing positive view. The narrative often reinforces negative stereotypes for comedic effect.

The show depicts Islam through broad and problematic stereotypes, particularly in relation to Middle Eastern themes and terrorism. These portrayals are used for shock humor, reinforcing negative perceptions without counterbalancing positive or nuanced views.

Toot's character and her background are often used to embody and exaggerate Jewish stereotypes for comedic effect, with the show frequently employing cultural references in a stereotypical manner. The humor often derives from reinforcing these stereotypes rather than satirizing bigotry against them.