El Chapo includes minor gay/bisexual characters (El Cholo, El Cano) whose identities are present but incidental to their primary roles as cartel members. The narrative neither affirms nor denigrates their queer identity, focusing instead on their involvement in the drug trade and its violent consequences. Their sexuality is a background detail, not a central theme.

The series consistently portrays Christianity, particularly Catholicism, through the lens of its adherents within the drug cartel, who exhibit profound hypocrisy. Characters like El Chapo display outward piety and devotion to saints while orchestrating extreme violence and illegal activities. The narrative uses this juxtaposition to highlight their moral corruption, without offering any significant counterbalancing positive portrayal of the faith within the show's context.