Empire features a prominent, complex, and affirming portrayal of Jamal Lyon, an openly gay protagonist. His journey navigates significant challenges, including family homophobia and industry prejudice, but ultimately emphasizes self-acceptance, resilience, and the eventual triumph of love and understanding, critiquing societal biases.

The show "Empire" features Angelica, a trans woman, portrayed with dignity and complexity as a talented singer and love interest for Jamal Lyon. The narrative depicts Jamal's journey of acceptance and love, framing any initial hesitation or societal prejudice as external challenges. This ultimately affirms the worth of trans lives and relationships, contributing to a net positive portrayal.

The film portrays Christianity with nuance, showcasing both the genuine solace and redemption it offers characters, and the hypocrisy or judgment sometimes exhibited by flawed adherents. The narrative often critiques bigotry expressed under the guise of faith, positioning the audience to sympathize with those victimized, rather than condemning the faith itself.