The show "Gutfeld!" frequently engages with LGBTQ+ themes and identities through a lens of satire and political commentary. Its portrayal often involves ridicule and criticism of LGBTQ+ issues, particularly gender identity and "woke" culture, presenting them in a predominantly negative light without significant counterbalancing perspectives.

Gutfeld! consistently portrays transsexual characters and themes in a negative light. The show frequently uses ridicule and mockery when discussing transgender identities, gender-affirming care, and related social issues. Its commentary often frames these topics as absurd or part of a 'woke' agenda, relying on stereotypes and dismissing the validity of trans experiences without affirming counterpoints.

The show frequently defends Christian values and traditions, often portraying them as foundational to American society. It tends to satirize or critique those who challenge or dismiss Christianity, positioning the faith in a sympathetic or affirmed light.

The show often portrays Islam through a critical lens, frequently associating it with extremism, geopolitical conflict, or perceived societal issues. It rarely offers nuanced or positive portrayals, tending to reinforce negative stereotypes.

When Judaism is addressed, the show typically expresses solidarity with Jewish people, particularly in discussions concerning antisemitism or support for Israel. It frames criticisms of Judaism or Jewish people as bigotry, aligning the narrative against such prejudice.