The series "Hollywood" offers a largely positive and affirming portrayal of LGBTQ+ characters, reimagining history to show queer individuals overcoming systemic homophobia to achieve success, love, and public acceptance. It critiques past prejudices while celebrating queer identity and relationships.

The series features Henrietta Lange, a trans woman screenwriter, whose portrayal is overwhelmingly positive. She is depicted with dignity, complexity, and agency, navigating societal challenges with resilience. The narrative consistently affirms her identity and worth, framing obstacles as external prejudices rather than inherent to her identity.

The series prominently features Jewish characters who face systemic anti-Semitism in post-war Hollywood. The narrative consistently condemns this prejudice, portraying the characters with dignity and highlighting the injustice of their discrimination.