House of Cards includes several characters with queer identities, notably Frank Underwood's bisexuality. These are depicted as facets of complex individuals, often intertwined with power dynamics and manipulation. The show neither explicitly affirms nor denigrates LGBTQ+ identity, treating it as incidental to the characters' overarching arcs and the series' themes of political ambition and control, resulting in a neutral portrayal.

House of Cards features a minor transsexual character, Connie, who appears briefly as a sex worker. Her identity is present but not central, serving a functional role in the narrative without being explicitly affirmed or denigrated. The portrayal is incidental, avoiding strong positive or negative thematic arcs.

The show consistently portrays Christianity, particularly its institutional and political manifestations, as a tool for manipulation and hypocrisy. Characters, most notably Frank Underwood, cynically exploit religious rhetoric and institutions for political gain, highlighting a pervasive lack of genuine faith among those in power.