Krypton features a prominent and positively depicted same-sex relationship between Lyta-Zod and Jayna-Zod. Their bond is integral to their characters and the plot, portrayed with dignity and complexity. The show normalizes their relationship within Kryptonian society, focusing on their personal and political struggles rather than their queer identity as a source of conflict.

The show features female characters like Lyta-Zod and Jayna-Zod, who are highly skilled Sagitari soldiers. They are depicted engaging in and winning physical combat against male opponents, utilizing hand-to-hand techniques and melee weapons.

The show features Jax-Ur, a character canonically established as male in DC Comics, portrayed as female in the series.

General Zod, a character consistently depicted as white in DC Comics and prior adaptations, is portrayed by a Black actor in the series. This constitutes a clear instance of a race swap.