Madam Secretary consistently portrays LGBTQ+ characters with dignity and respect. Key characters are openly queer, and their identities are treated as normal aspects of their lives. The series actively defends LGBTQ+ rights through storylines involving political attacks on gay individuals, affirming the worth of queer lives and love.

Madam Secretary's 'Break in Diplomacy' episode features a transgender student whose rights are championed by the US government. The portrayal is affirming, depicting the character with dignity and framing discrimination as an external injustice. The narrative advocates for transgender rights and respect.

The show portrays Christianity as a source of moral guidance and personal strength for several characters, often exploring ethical dilemmas through a faith-informed lens. Any negative portrayals are typically attributed to individual hypocrisy rather than the faith itself, maintaining an overall respectful tone.

The series consistently distinguishes between extremist groups and the broader Muslim faith, featuring diverse Muslim characters portrayed with dignity and complexity. It actively counters Islamophobic stereotypes, positioning the audience to sympathize with Muslim communities and individuals facing prejudice.

Judaism is depicted with respect and nuance, particularly through characters and storylines involving US-Israel relations and interfaith dialogue. The narrative highlights cultural and historical aspects without resorting to stereotypes.