Married to Medicine included a storyline where a male cast member faced allegations of a same-sex affair, generating significant marital drama. This plot point served as a catalyst for conflict within a heterosexual relationship, rather than a deep exploration of LGBTQ+ identity. The portrayal was incidental, neither strongly affirming nor denigrating queer lives, as the narrative focused on the allegations' impact on the marriage.

The show frequently depicts its cast members engaging in Christian practices, attending church, and discussing their faith as a source of strength and moral guidance. While individual characters may exhibit personal flaws or conflicts, the narrative generally presents Christianity as a positive and integral aspect of their lives, offering support and community without critiquing the faith itself.