Marvel's Cloak & Dagger does not feature any identifiable transsexual characters or themes. The show's narrative is centered on its two main protagonists and their journey, with no depiction of transgender identity or related issues.

Female characters like Tandy Bowen (Dagger) primarily rely on their superpowers for combat victories. Brigid O'Reilly, as a human police officer, engages in confrontations but does not achieve clear physical combat victories against multiple male opponents through skill or strength alone. No scenes depict a female character winning close-quarters physical combat against one or more male opponents without relying on superpowers or firearms.

The show adapts the Marvel Comics characters Cloak (Tyrone Johnson) and Dagger (Tandy Bowen), along with supporting characters like Brigid O'Reilly and Father Delgado. All main and significant legacy characters retain their established genders from the source material.

The main characters, Cloak (Tyrone Johnson) and Dagger (Tandy Bowen), are portrayed by actors whose races align with their established comic book depictions (Black and white, respectively). No significant race swaps of canonically established characters are present.