Ozark includes several LGBTQ+ characters, such as FBI Agent Maya Miller and Rachel Garrison, whose identities are presented factually and without prejudice. Their sexual orientations are incidental to their primary roles and character arcs, neither serving as a central theme for affirmation nor degradation. The show's portrayal is largely neutral, integrating queer identities into the narrative without significant focus or commentary.

The show portrays Christian figures and institutions as either hypocritical, easily corrupted, or ultimately powerless against the criminal underworld. Sincere adherents, like Pastor Mason Young, see their faith shattered and lives destroyed, while others, like the Snells, twist religious rhetoric to justify their violent actions. The narrative offers no significant counterbalancing positive portrayal of the faith, instead highlighting its fragility and failure in a morally compromised world.