Parenthood features a positive portrayal of LGBTQ+ characters through Renee and Michelle, a stable lesbian couple fully integrated into the Braverman family. The show depicts their relationship with dignity and normalizes their family unit. It also explores a character's journey from initial discomfort to acceptance, affirming queer identity and love without resorting to harmful stereotypes or negative outcomes.

Parenthood features Dylan, a transgender boy, whose identity is portrayed with dignity and respect. The narrative focuses on Max's developing feelings for Dylan, using the storyline to explore themes of acceptance and understanding without sensationalizing or problematizing Dylan's trans identity. The show's stance is empathetic and affirming.

The series portrays Judaism positively through Max's bar mitzvah storyline. It emphasizes the cultural and familial significance of Jewish traditions, showing the Braverman family respectfully engaging with and learning about their heritage. The narrative highlights the importance of honoring these customs without critique or negative stereotypes.