RESIDENT EVIL: Infinite Darkness does not feature any identifiable LGBTQ+ characters or themes. The story centers on its established protagonists and a bioterrorism incident, with no narrative elements touching upon queer identity or experiences. Therefore, the net impact is N/A.

RESIDENT EVIL: Infinite Darkness does not feature any identifiable transsexual characters or themes within its narrative. Consequently, there is no portrayal to evaluate against the provided rubric, resulting in an N/A rating for transsexual depiction.

The show features female characters like Claire Redfield and Shen May who participate in action sequences. However, their victories against male adversaries are primarily achieved through the use of firearms or against non-human biological threats, not through direct physical combat or melee weapon engagements as defined.

The series features established characters Leon S. Kennedy and Claire Redfield, both of whom retain their canonical genders from the Resident Evil video game franchise. All other significant characters are original to this series, thus precluding any gender swaps.

The main characters, Leon S. Kennedy and Claire Redfield, maintain their established racial depictions from the Resident Evil video game series. New characters introduced in this series do not constitute race swaps.