Scandal features prominent gay characters, notably Cyrus Beene, who is depicted with significant complexity, power, and agency. His relationships are central to his character arc and are treated with seriousness, avoiding harmful stereotypes. While his life is fraught with political intrigue and personal tragedy, these challenges are external to his sexual orientation, contributing to a net positive portrayal.

Scandal features a minor transsexual character, Marcus Walker's sister, whose identity becomes central to a political scandal involving a sex tape. The narrative portrays her identity as a source of vulnerability, but her brother fiercely protects her from public exposure. The show avoids explicit denigration, and the negative outcome is averted, resulting in a largely neutral portrayal focused on the political maneuvering rather than deep character exploration.

Scandal consistently portrays Christian adherents, particularly those in political power, as deeply hypocritical. The narrative frequently exposes characters who publicly espouse Christian values while engaging in corruption, deceit, and immoral acts, using their faith as a facade. The show's overall message critiques the moral failings and manipulative use of religion by those in power, without offering significant counterbalancing positive portrayals of the faith itself.