Sweet Magnolias features LGBTQ+ characters whose identities are portrayed with dignity and respect. Erik Whitley's past gay relationship is presented as a normal part of his history, and Isaac's birth father is revealed to be a gay man, handled without negative stereotypes. The show integrates these elements into the narrative in an affirming and empathetic manner.

The show adapts characters from the "Sweet Magnolias" novels. Helen Decatur and Erik Whitley, established as white in the source material, are portrayed by Black actors in the series.

The series consistently portrays Christianity as a positive force, emphasizing its role in community building, moral guidance, and personal resilience. Characters frequently find comfort and strength in their faith, and the church serves as a central, supportive institution in their lives.