The show features LGBTQ+ characters, notably Chris, whose coming out arc highlights the challenges of family prejudice, framed as an external negative force. He is depicted with dignity and agency. Nadia's bisexuality is also presented incidentally as part of her complex character. The overall portrayal is empathetic and affirming, critiquing homophobia while depicting queer characters respectfully.

The Cleaning Lady features Chris De La Rosa, a transgender character whose journey is central to a significant storyline. The show portrays her with dignity and agency, focusing on her family's evolving acceptance and support. While external challenges are present, the overall narrative affirms transgender identity, resulting in a net positive portrayal.

The protagonist, Thony De La Rosa, is an adaptation of the main character from the Argentinian series "La chica que limpia." The original character was portrayed as white/Latina, while the adapted character is portrayed by an actress of Asian descent, constituting a race swap.