The Good Wife consistently features LGBTQ+ characters and storylines, often exploring legal and social issues with empathy. Characters like Owen Cavanaugh and Jeffrey Agos are depicted with dignity and complexity, and the show generally critiques prejudice, affirming the worth of LGBTQ+ lives and rights.

The Good Wife features transsexual characters in multiple storylines, consistently portraying them with dignity and agency. The series uses legal drama to highlight and challenge societal prejudices and discrimination faced by trans individuals, particularly concerning identity and rights, ultimately taking an empathetic and affirming stance.

The show explores Christianity with nuance, depicting both the genuine faith and community of its adherents, as well as the human failings and hypocrisies within its institutions. The narrative often delves into the complexities of faith in the modern world, offering depth and respect rather than a blanket condemnation.

The show frequently portrays Muslim characters and their faith with sympathy and respect, often highlighting and critiquing the prejudice and discrimination they face. The narrative consistently positions the audience to understand and empathize with Muslim perspectives, debunking stereotypes.

Judaism is consistently portrayed with respect, showcasing the strength of its community, traditions, and legal complexities. Jewish characters are often depicted as principled and intelligent, and the show explores their faith with depth and understanding.