The Handmaid's Tale depicts LGBTQ+ characters, such as Emily and Moira, enduring extreme persecution under Gilead's oppressive regime. While showcasing horrific violence and discrimination, the narrative unequivocally condemns these acts. The show portrays these characters with dignity, resilience, and agency, affirming the worth of queer lives by framing their suffering as a consequence of external evil, not their identity.

The show portrays a fictional, extremist Christian fundamentalist regime (Gilead) as inherently oppressive, cruel, and misogynistic. Its 'Christian' ideology is used to justify systemic rape, torture, and the subjugation of women, with no significant counterbalancing positive portrayal of the faith itself within the narrative.

The show depicts Jewish people as victims of severe persecution, forced conversion, and 'resettlement' by the oppressive Gilead regime. The narrative clearly frames this bigotry as wrong, positioning the audience to sympathize with the victimized Jewish community and condemn the atrocities committed against them.