The series features multiple LGBTQ+ characters whose identities are integrated respectfully into the narrative. Characters like Sticky are gay, and Mr. Benedict is in a same-sex relationship, both portrayed with dignity. The show also includes a non-binary character, Rhonda, whose pronouns are acknowledged without issue, contributing to an affirming and inclusive environment.

The character Sticky Washington, established as white in the original book series, is portrayed by a Black actor in the 2021 adaptation, constituting a race swap.

The narrative strongly endorses alternative family structures, depicting a "chosen family" of gifted orphans and isolated children who find belonging and support with an unconventional mentor. The film celebrates non-biological bonds and the idea that family is defined by love and shared purpose, rather than traditional structures.