The Resident consistently portrays LGBTQ+ characters with dignity and respect, integrating their identities into the narrative without resorting to stereotypes or making them a source of misery. The show normalizes queer relationships and addresses related social issues with empathy, contributing to an overall affirming depiction.

The Resident features a transgender character, Jess, whose storyline focuses on her medical journey and family acceptance. The portrayal is affirming, depicting her with dignity and resolving initial familial hesitation with empathy and support, ultimately validating her identity.

The show frequently depicts Christian characters and patients whose faith influences their medical decisions or provides comfort. While the narrative may critique specific actions or interpretations of faith that lead to medical challenges, it generally portrays Christianity with respect and nuance, acknowledging it as a source of strength and community for individuals.