The West Wing generally portrays LGBTQ+ characters and themes positively. Key storylines, like that of Kevin Kahn, demonstrate profound empathy and advocate for dignity against prejudice. Other characters are integrated neutrally, avoiding stereotypes. The show consistently features characters who challenge discriminatory policies, framing obstacles as external forces rather than inherent to queer identity, thus affirming LGBTQ+ lives.

The show consistently portrays Christianity, particularly Catholicism, with respect and depth through President Bartlet's character, exploring his faith as a source of moral guidance and personal struggle. It delves into the complexities of faith in public life, often aligning the narrative with the virtues of the religion.

The West Wing actively works to counter negative stereotypes of Islam, distinguishing between extremist groups and the peaceful majority. The narrative condemns Islamophobia and portrays Muslim characters and the religion itself with nuance and sympathy, particularly in discussions of foreign policy and domestic prejudice.

Judaism is depicted through prominent characters like Josh Lyman and Toby Ziegler, exploring their cultural and religious identity, family heritage, and the challenges of being Jewish in American politics. The portrayal is respectful, highlighting the intellectual and moral dimensions of their faith.