The Witcher respectfully portrays several LGBTQ+ characters, most notably Ciri's genuine and intimate relationship with Mistle, which offers solace amidst external hardships. Other characters like Jaskier and Philippa Eilhart have their queer identities depicted incidentally and without negative framing. The show's overall stance is empathetic, leading to a net positive impact.

The show features Ciri, who, after receiving combat training, demonstrates her proficiency with a sword by defeating multiple male opponents in direct physical confrontations.

The show features several characters, including Yennefer and Fringilla Vigo, who were canonically depicted or widely understood as white in the source novels and games, but are portrayed by actors of different races in the adaptation.