This Is Us offers a primarily positive portrayal of LGBTQ+ characters, most notably through Tess Pearson's coming out and subsequent relationships. Her journey is handled with sensitivity, parental support, and dignity, affirming her identity as a natural part of her character arc. The show avoids harmful stereotypes, presenting her experiences as normal and valid.

The show portrays Christianity as a significant source of comfort, community, and moral guidance for many characters, particularly the Pearson family. While characters grapple with their faith, the narrative treats these personal journeys with empathy and respect, affirming its role in their lives.

Judaism is depicted through Toby Damon and his family, showcasing traditions like weddings and holidays with respect and authenticity. The narrative integrates these practices as a cherished part of his cultural and religious identity, without any negative framing.